Exosome therapy is well-known in aesthetic medicine, and the potential effectiveness of exosomes in the knee osteoarthritis is attracting attention.

 

This article will focus on the most advanced regenerative medicine technology we offer and give a detailed explanation of exosome therapy.

 

If you are suffering from knee pain or restricted movement, it may be worth considering exosome therapy as a new treatment option.

 

• What are exosomes
• Types of exosomes
  ・Derived from umbilical cord (Wharton's jelly)
  ・Derived from adipocytes
  ・Derived from dental pulp
• People for whom exosomes are recommended
• Exosome treatment methods
• Types of treatment plans
• International approval standards
• Matters that require attention
  ・About side effects and risks
  ・Those who cannot receive the treatment
  ・Those who need medical supervision
• The price of exosomes
• How to make a reservation

 

What are exosomes

 

Exosomes are very small granular substances with a diameter of 50-150mm that are secreted by cells.

 

They can be found in various types of cells and biological fluids (blood, urine, saliva, etc.) and plays an important role in maintaining health and disease progression.

 

Exosomes are a type of vesicle which function as mediators of intracellular signaling and intercellular communication, and act on damaged or dysfunctional cells.

 

In recent years, exosomes have not only attracted attention in the field of aesthetic medicine, but also in the field of regenerative medicine and immunotherapy for cancer and other diseases.

 

We offer exosome therapy for arthritis pain.

 

Types of exosomes

 

There are three types of exosomes which are derived from the following sources.

 

・Derived from umbilical cord (Wharton's jelly)

・Derived from adipocytes

・Derived from dental pulp

 

Derived from umbilical cord (Wharton's jelly)

 

It is extracted from the umbilical cord that connects the fetus with the placenta of the mother.

It is said that only about 1% of the umbilical cord is available in Japan, making it a very rare and valuable part of the body.

 

The umbilical cord not only contains a large number of hematopoietic stem cells that produce red blood cells, white blood cells, and platelets, but also has the ability to regenerate hematopoietic stem cells.

It is therefore used to treat blood disorders and immune system diseases sometimes.

 

The cells that can be harvested from the umbilical cord have high cellular activity and are said to be more active than those derived from fat cells.

 

The exosomes we use for treatment are derived from the umbilical cord.

 

Derived from adipocytes

 

It is harvested from adipose tissue from both men and women of all ages.

It is said that about 70% is available in Japan and is characterized by its low cost.

 

Cell activity varies greatly depending on the age of the person from whom the fat cells are harvested, and fat cells which are harvested from younger people are considered to have higher activity.

 

Derived from dental pulp

 

It is harvested from baby teeth.

The nerve portion (pulp cells) at the center of human teeth is surrounded by hard enamel and dentin, making it less susceptible to external influences and is believed to contain stem cells of very high quality.

Like umbilical cord, it can be extracted from young stem cells and is considered to have high cell activity.

 

People for whom exosomes are recommended

 

• Those who are diagnosed with knee osteoarthritis
• Those who have failed to benefit from other regenerative therapies such as PRP, APS, GOLDIC, stem cell culture supernatant, and non-culture stem cell therapy.
• Those who do not respond to hyaluronic acid injections
• Those for whom rehabilitation is ineffective

 

The exosomes we use are derived from umbilical cords, which are the rarest and most valuable, and has the highest cell activity.

If any of the above apply to you, we hope you will consider using exosomes.

 

Exosome treatment methods

 

Exosome treatment methods include two types.

 

・Injection

・Intravenous infusion

 

 

Types of treatment plans

 

There are two types of exosome therapy as following.

 

・Standard exosome

・Premium exosome

 

The difference between the two lies in the different content of exosome.

 

・Standard：18.9 million /ml

・Premium：3 billion/ml

 

The Premium type contains approximately 158 times more exosomes than Standard type.

 

International approval standards

 

We culture and produce exosomes in compliance with the only international guideline defining EXOSOME, which was set by the International Society for Extracellular Vesicles.

 

Matters that require attention

 

About side effects and risks

 

Since exosomes are biomolecules, but not synthetic substances, they are generally considered safe.

However, it is important to note that in rare cases an allergic reaction may occur.

 

In rare cases, numbness may occur after infusion therapy, but rest assured that it will settle down over time.

 

It is also important to note that blood donation may be restricted after treatment due to the injection of biomolecular solution.

 

Those who cannot receive the treatment

 

・Those who have been diagnosed with a malignant tumor and have not been in remission for 5 years

・Those who are undergoing treatment for malignant tumors

 

Exosomes may promote the proliferation of cancer cells, so those who fall under the above conditions cannot receive exosome therapy.

 

Those who need medical supervision

 

■Past medical history, current medical history, surgical history, and medications (including supplements) currently being taken

■Pregnancy, childbirth, and breastfeeding

■Allergies

 

If you have any other concerns or questions about your health, please let us know in advance.

 

The price of exosomes

 

■Standard exosome

・1 bottle: 135,000 yen

・6 bottles: 600,000 yen (100,000 yen per bottle)

・12 bottles: 1,000,000 yen (83,333 yen per bottle)

 

■Premium exosome

・1 bottle: 270,000 yen

・6 bottles: 1,200,000 yen (200,000 yen per bottle)

・12 bottles:2,000,000 yen (166,666 yen per bottle)

 

If you buy in bulk, the price will be more reasonable.

 

How to make a reservation

 

Please contact us first by phone (03-5295-2020) or via our official line.